Τίτλος:
Lipid profile is associated with treatment regimen in a large cohort of children and adolescents with Type 1 diabetes mellitus: a study from the international SWEET database
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: To examine the effect of pump vs injection therapy on the lipid profile of children with Type 1 diabetes mellitus. Methods: A cross-sectional analysis of the lipid profile of children aged ≤ 18 years with Type 1 diabetes mellitus from SWEET, an international diabetes registry, was conducted with a focus on the effect of treatment regimen. Dyslipidaemia was defined as LDL cholesterol ≥2.6 mmol/l or non-HDL cholesterol ≥3.1 mmol/l. LDL and non-HDL cholesterol values among 14 290 children (52% boys, 51% receiving pump therapy) from 60 SWEET centres were analysed by linear and logistic regression analysis adjusted for sex, age, diabetes duration, HbA1c and BMI-standard deviation score group, region, and common interactions between age, sex, HbA1c and BMI. Results: This study confirmed the established associations of increased lipids with female sex, age, diabetes duration, HbA1c and BMI. LDL and non-HDL cholesterol levels were lower in the pump therapy group compared to the injection therapy group [LDL cholesterol: injection therapy 2.44 mmol/l (95% CI 2.42 to 2.46) vs pump therapy 2.39 mmol/l (95% CI 2.37–2.41), P<0.001; non-HDL cholesterol: injection therapy 2.88 mmol/l (95% CI 2.86 to 2.90) vs pump therapy 2.80 mmol/l (95% CI 2.78–2.82), both P<0.0001]. Similarly, the odds ratios for LDL cholesterol ≥2.6 mmol/l [0.89 (95% CI 0.82–0.97)] and non-HDL cholesterol ≥3.1 mmol/l [0.85 (0.78 to 0.93)] were significantly lower in the pump therapy group, even after all adjustments. Conclusions: Our results indicate that pump therapy is associated with a better lipid profile. © 2019 Diabetes UK
Συγγραφείς:
Kosteria, I.
Schwandt, A.
Davis, E.
Jali, S.
Prieto, M.
Rottembourg, D.
the SWEET study group
Περιοδικό:
Diabetic Medicine
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
hemoglobin A1c; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; antidiabetic agent; high density lipoprotein cholesterol; insulin; lipid; low density lipoprotein cholesterol, adolescent; Article; child; cohort analysis; cross-sectional study; data base; disease duration; disease registry; dyslipidemia; female; hemoglobin blood level; high density lipoprotein cholesterol level; human; insulin dependent diabetes mellitus; insulin treatment; intermethod comparison; lipid fingerprinting; low density lipoprotein cholesterol level; major clinical study; male; multicenter study; standard; blood; body weight; comparative study; complication; dyslipidemia; factual database; glucose blood level; injection; insulin dependent diabetes mellitus; insulin infusion; register; sex factor, Adolescent; Blood Glucose; Body Weight; Child; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Databases, Factual; Diabetes Mellitus, Type 1; Dyslipidemias; Female; Humans; Hypoglycemic Agents; Injections; Insulin; Insulin Infusion Systems; Lipids; Male; Registries; Sex Factors
