Περίληψη:
The increase in human life expectancy is accompanied by age-related cognitive and motor disability, thus raising the demand for strategies toward healthy aging. This requires understanding the biology of normal aging and late-life functional phenotypes. Genetic model organisms, such as Drosophila melanogaster, can help identifying evolutionary conserved mechanisms underlying aging. Longitudinal assessment of motor performance of more than 1000 individual flies revealed age-related motor performance decline and specific late-life motor disabilities. This allows defining heath- and ill-span and scoring late-life quality of individual flies. As in mammals, including humans, onset, duration, severity, and progression dynamics of decline are heterogenic and characterized by both, progressive worsening and sudden late-life events. Flies either become increasingly incapacitated by accumulating disability over multiple days prior to death, or they escape disability until few hours prior to death. Both late-life trajectories converge into a terminal stage characterized by stereotypical signs of functional collapse and death within 3 hours. Drosophila can now be used to evaluate life prolonging manipulations in the context of late-life quality. High sugar diet increases lifespan and late-life quality, whereas lifespan prolonging antioxidant supplementation has either no, or negative effects on late-life quality, depending on base diet and gender. © Gaitanidis et al.
Συγγραφείς:
Gaitanidis, A.
Dimitriadou, A.
Dowse, H.
Sanyal, S.
Duch, C.
Consoulas, C.
Λέξεις-κλειδιά:
aging; animal; animal model; Drosophila melanogaster; female; longevity; longitudinal study; male; physiology, Aging; Animals; Drosophila melanogaster; Female; Longevity; Longitudinal Studies; Male; Models, Animal; Physical Functional Performance
