Τίτλος:
Orbital metastases of invasive lobular breast carcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Breast cancer is the main site of origin of orbital metastatic disease. Although invasive lobular breast carcinoma accounts for 10-15% of all breast cancer cases, it has been noticed that it metastasizes to the orbit more often compared to breast cancer of no special type (NST). The pathogenesis of this metastasis is not entirely understood; however, it seems that the unique tissue-specific characteristics of orbital microenvironment might contribute to metastatic disease in this particular site. Given the increasing survival of breast cancer patients and the prolonged metastatic potential of invasive lobular breast carcinoma, it is possible that the incidence of this rare metastasis might increase in the future. The purpose of this review is to present clinical manifestations, immunohistochemical characteristics and therapeutic options for orbital metastases from invasive lobular carcinoma. © 2019 IOS Press and the authors. All rights reserved.
Συγγραφείς:
Tsagkaraki, I.M.
Kourouniotis, C.D.
Gomatou, G.L.
Syrigos, N.K.
Kotteas, E.A.
Περιοδικό:
Breast Diseases
Λέξεις-κλειδιά:
antineoplastic agent; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor, blindness; breast carcinoma; cancer hormone therapy; cancer radiotherapy; cancer surgery; eye pain; histopathology; human; immunohistochemistry; invasive lobular breast carcinoma; metastasis potential; orbit metastasis; priority journal; protein expression; ptosis (eyelid); Review; tissue specificity; tumor microenvironment; biopsy; breast; breast tumor; female; lobular carcinoma; orbit tumor; Paget nipple disease; pathology, Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Female; Humans; Immunohistochemistry; Orbital Neoplasms; Tumor Microenvironment
