Περίληψη:
Background: The childhood peak of brain tumors suggests that early-life exposures might have a role in their etiology. Hence, we examined in the Greek National Registry for Childhood Hematological Malignancies and Solid tumors (NARECHEM-ST) whether perinatal and early-life risk factors influence the risk of childhood brain tumors. Methods: In a nationwide case-control study, we included 203 cases (0–14 years) with a diagnosis of brain tumor in NARECHEM-ST (2010–2016) and 406 age-, sex-, and center-matched hospital controls. Information was collected via interviews with the guardians and we analyzed the variables of interest in multivariable conditional logistic regression models. Results: Instrument-assisted delivery was associated with higher (OR: 7.82, 95%CI: 2.18–28.03), whereas caesarean delivery with lower (OR: 0.67, 95%CI: 0.45-0.99) risk of childhood brain tumors, as compared to spontaneous vaginal delivery. Maternal alcohol consumption during pregnancy (OR: 2.35, 95%CI: 1.45–3.81) and history of living in a farm (OR: 4.98, 2.40–10.32) increased the odds of childhood brain tumors. Conversely, higher birth order was associated with lower risk (OR for 2nd vs. 1st child: 0.60, 95%CI: 0.40-0.89 and OR for 3 rd vs. 1 st : 0.34, 95%CI: 0.18-0.63). Birth weight, gestational age, parental age, history of infertility, smoking during pregnancy, allergic diseases, and maternal diseases during pregnancy showed no significant associations. Conclusions: Perinatal and early-life risk factors, and specifically indicators of brain trauma, exposure to toxic agents and immune system maturation, might be involved in the pathogenesis of childhood brain tumors. Larger studies should aim to replicate our findings and examine associations with tumor subtypes. © 2019 Elsevier Ltd
Συγγραφείς:
Georgakis, M.K.
Dessypris, N.
Papadakis, V.
Tragiannidis, A.
Bouka, E.
Hatzipantelis, E.
Moschovi, M.
Papakonstantinou, E.
Polychronopoulou, S.
Sgouros, S.
Stiakaki, E.
Pourtsidis, A.
Psaltopoulou, T.
Petridou, E.T.
Bourgioti, C.
Dana, H.
Papadopoulos, S.
Sfakianos, G.
Themistocleous, M.
Stefanaki, K.
Strantzia, K.
Zountsas, B.
Vakis, A.
Manolitsi, K.
Kelekis, N.
Papathanasiou, M.
Gkantaifi, A.
Koutzoglou, M.
Koletsa, T.
Nikas, I.
Zacharoulis, S.
Prassopoulos, P.
Orfanides, G.
Panagiotis, P.
Zerris, V.
Friehs, G.
Vyziotis, A.
Patsouris, E.
NARECHEM-ST CNS tumors Working Group
Λέξεις-κλειδιά:
toxic substance, adolescent; adult; alcohol consumption; allergic disease; Article; astrocytoma; birth weight; brain tumor; cancer risk; cesarean section; child; childhood cancer; controlled study; correlation analysis; ependymoma; gestational age; glioma; Greece; high risk patient; human; immune system; infant; infertility; instrument assisted delivery; interview; intracranial tumor; intraspinal embryonal tumor; major clinical study; maternal disease; multicenter study; multivariate logistic regression analysis; newborn; obstetric procedure; parental age; pathogenesis; perinatal period; pregnancy; priority journal; risk assessment; risk factor; smoking; solid malignant neoplasm; traumatic brain injury; vaginal delivery; young adult; birth order; brain tumor; case control study; drinking behavior; female; hypersensitivity; male; prenatal exposure; preschool child; risk factor; statistical model, Adolescent; Alcohol Drinking; Birth Order; Birth Weight; Brain Neoplasms; Case-Control Studies; Child; Child, Preschool; Female; Greece; Humans; Hypersensitivity; Infant, Newborn; Logistic Models; Male; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Smoking
