Περίληψη:
Purpose: To investigate the association of the hypothalamic-pituitary-testicular (HPT) axis with pro- and anti- oxidation, in relation to puberty and obesity in boys, before and after an aerobic exercise bout. Methods: This is a cross-sectional human observational study of 92 healthy normal-weight, obese pre- and early- pubertal boys that underwent a blood sampling, before, and after an aerobic exercise bout at 70% VO2max, until exhaustion. LH, FSH, total testosterone (tT) and markers of pro- (TBARS and PCs) and anti- (GSH, GSSG, GPX, catalase, TAC) oxidation were measured. Results: Baseline LH, FSH, and tT concentrations were greater in early, than in pre- pubertal boys, independently of weight status. Post-exercise, LH concentrations decreased in early pubertal boys while FSH concentrations did not change in any of the studied groups. Baseline and post-exercise tT concentrations were lower in obese than in normal-weight early pubertal boys, while baseline and post-exercise LH and FSH concentrations did not differ between these groups. Post-exercise tT concentrations increased in early pubertal obese boys. Baseline LH, FSH and tT concentrations correlated positively with baseline anti-oxidation markers concentrations in pre-pubertal boys. Baseline tT concentrations correlated positively with the increase of TAC concentrations in early pubertal normal-weight boys. In all boys, baseline LH concentrations were the best positive predictors for the exercise-associated increase of TAC concentrations. Conclusions: It appears that the HPT axis maturation during puberty (in particular its LH and testosterone components) is positively associated with the increase of anti-oxidation during a bout of aerobic exercise. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Paltoglou, G.
Avloniti, A.
Chatzinikolaou, A.
Stefanaki, C.
Papagianni, M.
Papassotiriou, I.
Fatouros, I.G.
Chrousos, G.P.
Kanaka-Gantenbein, C.
Mastorakos, G.
Λέξεις-κλειδιά:
antioxidant; carbonyl derivative; catalase; glutathione; glutathione disulfide; luteinizing hormone; testosterone; thiobarbituric acid reactive substance; catalase; follitropin; glutathione; luteinizing hormone; testosterone; thiobarbituric acid reactive substance, adolescent; adolescent obesity; aerobic exercise; Article; child; controlled study; cross-sectional study; endocrine function; human; hypothalamic pituitary testicular axis; major clinical study; male; observational study; oxidation; priority journal; puberty; blood; childhood obesity; exercise; metabolism; oxidative stress; physiology; puberty, Catalase; Child; Cross-Sectional Studies; Exercise; Follicle Stimulating Hormone; Glutathione; Humans; Luteinizing Hormone; Male; Oxidative Stress; Pediatric Obesity; Puberty; Testosterone; Thiobarbituric Acid Reactive Substances
