Τίτλος:
Nectin-1 Expression in Colorectal Cancer: Is There a Group of Patients with High Risk for Early Disease Recurrence?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Despite improvements in therapy of colorectal cancer, some patients will present occurrence of recurrence either locally or distantly. Tumor metastasis constitutes the major cause of cancer-associated morbidity and mortality. Nectin-1 belongs to the family of immunoglobulin-like cell adhesion molecules that contribute to the formation of cell-cell adhesions and regulate a series of cellular activities including cell polarization, differentiation, movement, proliferation, and survival. Expression of Nectin-1 in malignant tumors has been associated with aggressive tumor phenotypes. Objectives: The aim of the present study was to assess Nectin-1 expression patterns in colorectal cancer and to investigate its clinical significance. Methods: Nectin-1 expression was assessed via immunohistochemistry in surgical specimens of a cohort comprised of 111 patients with primary resectable colorectal cancer. Results were correlated with clinicopathological characteristics and survival data. Progression-free survival was defined as the primary outcome of the present study. Results: Nectin-1 was strongly expressed in the cytoplasm of colorectal cancer cells. High Nectin-1 expression was associated with advanced stage of disease (p = 0.012) and lymph node metastasis (p = 0.007). Progression-free survival of patients exhibiting high expression of Nectin-1 in the first 36 months after surgery was significantly worse compared to patients with low expression of Nectin-1 (55.7%, 95% CI = 47-70, vs. 82.1%, 95% CI = 69-93, p = 0.014) and independent of other clinicopathological characteristics (HR = 0.389, 95% CI = 0.156-0.972, p = 0.043). Conclusion: Nectin-1 expression in colorectal cancer is associated with a significantly worse 3-year progression-free survival identifying therefore a group of patients with high risk for early disease recurrence. © 2019 S. Karger AG, Basel.
Συγγραφείς:
Tampakis, A.
Tampaki, E.C.
Nonni, A.
Droeser, R.
Posabella, A.
Tsourouflis, G.
Kontzoglou, K.
Patsouris, E.
Von Flüe, M.
Kouraklis, G.
Περιοδικό:
Oncology (Switzerland)
Λέξεις-κλειδιά:
nectin 1; nectin; NECTIN1 protein, human, adult; advanced cancer; aged; Article; cancer cell; cancer prognosis; cancer survival; cancer tissue; clinical feature; clinical outcome; cohort analysis; colorectal cancer; controlled study; correlation analysis; cytoplasm; female; high risk patient; histopathology; human; human tissue; immunohistochemistry; lymph node metastasis; major clinical study; male; middle aged; postoperative period; priority journal; progression free survival; protein expression; protein function; recurrence risk; risk assessment; very elderly; cancer staging; colorectal tumor; gene expression regulation; metabolism; pathology; retrospective study; treatment outcome; upregulation, Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Cytoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; Middle Aged; Nectins; Neoplasm Staging; Progression-Free Survival; Retrospective Studies; Risk Assessment; Treatment Outcome; Up-Regulation
