Περίληψη:
In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS-R). To further characterize the prognostic significance of chromosome 17 abnormalities we analyzed the hematologic and prognostic characteristics of 548 adult patients with MDS treated with 5-azacytidine through the Hellenic 5-azacytidine registry and found 32 patients with a chromosome 17 abnormality (6 with i[17q], 15 with -17, 3 with add[17p] and the rest with other rarer abnormalities, mostly translocations). The presence of a chromosome 17 abnormality was correlated with poor prognostic features (high IPSS, IPSS-R, and WPSS scores) and a low overall survival rate (15.7 vs 36.4 months for patients without chromosome 17 abnormalities, Kaplan–Meier, Log Rank P < 0.00001), but these results were confounded by the fact that most (92.3%) of the cases with a chromosome 17 abnormality (with the exception of i(17q) that was found in all cases as an isolated abnormality) were found in the context of a complex karyotype. Nevertheless, one should not ignore the contribution of chromosome 17 abnormalities to the prognostic significance of a complex karyotype since 33.8% of complex karyotypes encompassed a chromosome 17 abnormality. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Συγγραφείς:
Diamantopoulos, P.
Koumbi, D.
Kotsianidis, I.
Pappa, V.
Symeonidis, A.
Galanopoulos, A.
Zikos, P.
Papadaki, H.A.
Panayiotidis, P.
Dimou, M.
Hatzimichael, E.
Vassilopoulos, G.
Delimpasis, S.
Mparmparousi, D.
Papageorgiou, S.
Variami, E.
Kyrtsonis, M.-C.
Megalakaki, A.
Kotsopoulou, M.
Repousis, P.
Adamopoulos, I.
Kontopidou, F.
Christoulas, D.
Kourakli, A.
Tsokanas, D.
Konstantinos Papoutselis, M.
Kyriakakis, G.
Viniou, N.-A.
the Hellenic MDS study group
Λέξεις-κλειδιά:
azacitidine; antineoplastic antimetabolite; azacitidine, adult; Article; cancer prognosis; cancer registry; cancer regression; chromosome 17; chromosome aberration; chromosome addition; chromosome deletion; chromosome inversion; chromosome translocation; correlation analysis; female; human; International Prognostic Scoring System; Kaplan Meier method; karyotype; major clinical study; male; multiple cycle treatment; myelodysplastic syndrome; overall survival; priority journal; prognostic assessment; retrospective study; treatment outcome; World Health Organization classification based Prognostic Scoring System; aged; genetics; middle aged; myelodysplastic syndrome; prognosis; very elderly, Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Chromosomes, Human, Pair 17; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis
