Τίτλος:
Birth weight related essential, non-essential and conditionally essential amino acid blood concentrations in 12,000 breastfed full-term infants perinatally
Περίληψη:
Essential, non-essential and conditionally essential amino acid blood concentrations play a critical role in newborns. We aimed to quantitate most of these amino acids in the blood of full-term breastfed infants, perinatally and correlate the obtained values with their birth weight. Breastfed full-term infants (n = 12,000; 6000 males, 6000 females) with birth weight 2000–4000 g were divided into 4 equal groups: Group A, 2000–2500 g; B, 2500–3000 g; C, 3000–3500 g and D, 3500–4000 g. Blood samples as Dried Blood Spots (DBS) were collected on the 3rd day of life and analyzed via liquid chromatography-tandem mass spectrometry (LC-MS/MS) protocol. Blood concentrations of the amino acids, Phenylalanine, Leucine, Glutamine, Ornithine, Alanine, Tyrosine and Glycine in full-term breastfed newborns, were found to be related to their birth weight, perinatally. On the contrary, no relationship between birth weight and blood concentrations of the amino acids Valine, Methionine, Citrulline and Arginine was found. Due to the number of the samples, data from this study could be applied as neonatal screening reference values for full-term breastfed newborns in relation to their birth weight. © 2020 Medisinsk Fysiologisk Forenings Forlag (MFFF).
Συγγραφείς:
Manta-Vogli, P.D.
Schulpis, K.H.
Loukas, Y.L.
Dotsikas, Y.
Λέξεις-κλειδιά:
alanine; arginine; asparagine; aspartic acid; citrulline; cysteine; essential amino acid; glutamic acid; glutamine; glycine; histidine; isoleucine; leucine; lysine; methionine; nonessential amino acid; ornithine; phenylalanine; proline; serine; threonine; tryptophan; tyrosine; valine; essential amino acid, adult; amino acid blood level; Article; birth weight; blood sampling; breast feeding; controlled study; dried blood spot testing; female; human; liquid chromatography-mass spectrometry; major clinical study; male; newborn; newborn screening; perinatal period; priority journal; quantitative analysis; reference value; blood, Amino Acids, Essential; Birth Weight; Breast Feeding; Female; Humans; Infant, Newborn; Male
