Τίτλος:
Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: To examine for differences in circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) in patients with and without diabetic peripheral neuropathy (DPN). Methods: A total of 105 participants were included: 50 patients with type 2 diabetes (T2DM) and DPN, 30 patients with T2DM without DPN and 25 healthy individuals. CPCs and 6 different EPCs phenotypes were assessed with flow cytometry. We also measured plasma levels of vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF-1), vascular cell adhesion protein-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM) and tumor necrosis factor a (TNFa). Results: No difference was observed in the number of CPCs among the 3 groups. Patients with DPN had higher numbers of all 6 EPCs phenotypes when compared with patients without DPN and higher number of 5 EPCs phenotypes when compared with healthy individuals. Plasma VEFG, VCAM-1, ICAM-1 and TNFa levels did not differ among the 3 groups. Patients with DPN had lower SDF-1 levels in comparison with healthy individuals. Conclusion: Circulating EPCs are increased while SDF-1 levels are decreased in the presence of DPN. Our findings suggest that DPN may be associated with impaired trafficking of EPCs and impaired EPCs homing to the injured endothelium. © 2020 Elsevier Inc.
Συγγραφείς:
Eleftheriadou, I.
Dimitrakopoulou, N.
Kafasi, N.
Tentolouris, A.
Dimitrakopoulou, A.
Anastasiou, I.A.
Mourouzis, I.
Jude, E.
Tentolouris, N.
Περιοδικό:
Journal of Diabetes and its Complications
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
Λέξεις-κλειδιά:
CD133 antigen; CD34 antigen; dipeptidyl peptidase IV inhibitor; glucose; hemoglobin A1c; insulin; intercellular adhesion molecule 1; metformin; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; tumor necrosis factor; vascular cell adhesion molecule 1; vasculotropin; vasculotropin receptor 2, adult; ankle pressure; Article; blood sampling; cardiovascular risk; cell adhesion; cell isolation; chronic kidney failure; controlled study; cross-sectional study; diabetic nephropathy; diabetic neuropathy; diabetic patient; diabetic retinopathy; disease duration; endothelial progenitor cell; female; flow cytometry; glucose blood level; human; human cell; major clinical study; male; microalbuminuria; middle aged; non insulin dependent diabetes mellitus; observational study; pathogenesis; peripheral neuropathy; physical examination; priority journal; protein blood level; aged; blood; case control study; complication; diabetic neuropathy; endothelial progenitor cell; non insulin dependent diabetes mellitus; pathology; peripheral neuropathy, Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Endothelial Progenitor Cells; Female; Flow Cytometry; Humans; Male; Middle Aged; Peripheral Nervous System Diseases
DOI:
10.1016/j.jdiacomp.2019.107517
