Τίτλος:
Passive smoking acutely affects the microcirculation in healthy non-smokers
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Acute effects of passive smoking on microcirculation have not been sufficiently studied. The aim of the present study was to detect microcirculatory alterations in healthy non-smokers after passive exposure to cigarette smoke, utilizing the Near Infrared Spectroscopy method combined with the vascular occlusion technique. Methods: Sixteen (9 females, age: 34 ± 9 years) non-smoking, healthy volunteers were exposed to passive smoking for 30 min in a temperature-controlled environment. Smoke concentration was monitored with a real-time particle counter. The following microcirculatory parameters were estimated: baseline tissue oxygen saturation (StO2); StO2 decrement after vascular occlusion (indicating the oxygen consumption rate); StO2incremental response after vascular occlusion release (reperfusion rate); the time period where the StO2 signal returns to the baseline values after the hyperemic response. Results: Baseline StO2 (79.6 ± 6.4 vs. 79 ± 8%, p = 0.53) as well as the time needed for StO2 to return to baseline levels (138.2 ± 26.5 vs. 142.1 ± 34.6 s, p = 0.64) did not significantly differ before vs. after passive smoking exposure. Oxygen consumption rate decreased after 30 min exposure to passive smoking (from 12.8 ± 4.2 to 11.3 ± 2.8%/min, p = 0.04); Reperfusion rate also significantly decreased (from 5.6 ± 1.8 to 5 ± 1.7%/s, p = 0.04). Conclusions: Our results suggest that acute exposure to passive smoking delays peripheral tissue oxygen consumption and adversely affects microcirculatory responsiveness after stagnant ischemia in healthy non-smokers. © 2019 Elsevier Inc.
Συγγραφείς:
Linardatou, V.
Karatzanos, E.
Panagopoulou, N.
Delis, D.
Kourek, C.
Rovina, N.
Nanas, S.
Vasileiadis, I.
Περιοδικό:
Microvascular Research
Εκδότης:
Academic Press Inc.
Λέξεις-κλειδιά:
adult; Article; blood vessel occlusion; environmental temperature; female; human; human experiment; hyperemia; ischemia; male; microcirculation; muscle blood flow; near infrared spectroscopy; normal human; oxygen consumption; passive smoking; priority journal; reperfusion; skeletal muscle; tissue oxygenation; adverse event; blood flow; middle aged; oxygen consumption; passive smoking; pathophysiology; pilot study; time factor; vascularization; young adult, Adult; Female; Healthy Volunteers; Humans; Hyperemia; Male; Microcirculation; Middle Aged; Muscle, Skeletal; Non-Smokers; Oxygen Consumption; Pilot Projects; Regional Blood Flow; Spectroscopy, Near-Infrared; Time Factors; Tobacco Smoke Pollution; Young Adult
DOI:
10.1016/j.mvr.2019.103932
