Τίτλος:
Menstrual disorders and androgen-related traits in young women with type 1 diabetes mellitus: A clinical study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate possible causes of menstrual disorders and androgen-related traits in young women with type 1 diabetes mellitus (T1DM). Methods: Fifty-three women with T1DM (duration 8.0 ± 5.6 years), 41 women with (polycystic ovary syndrome) PCOS, and 51 controls matched for age (19.4 ± 4.3 years vs. 21.2 ± 2.7 years vs. 20.8 ± 3.1 years; P>.05) and body mass index (BMI) (22.2 ± 2.7 kg/m2 vs. 21.9 ± 2.0 kg/m2 vs. 21.4 ± 1.9 kg/m2; P>.05) were prospectively recruited. Results: Two women (3.8%) in the T1DM group had not experienced menarche (at 15.5 and 16.6 years); of the rest, 23.5% had oligomenorrhea, 32.1% hirsutism, and 45.3% had acne. The age at menarche was delayed in the T1DM group compared to controls (12.7 ± 1.3 vs. 12.0 ± 1.0 years; P = .004), while no difference was observed with the polycystic ovary syndrome (PCOS) group (12.4 ± 1.2 years). There were no differences in total testosterone (0.43 ± 0.14 ng/mL vs. 0.39 ± 0.14 ng/mL; P>.05), dehydroepiAândrosterone sulfate (DHEA-S) (269 ± 112 μg/dL vs. 238 ± 106 μg/dL; P>.05) or Δ4-androstenedione (2.4 ± 1.3 ng/mL vs. 1.9 ± 0.5 ng/mL; P>.05) concentrations between T1DM and controls. However, patients with T1DM had lower sex hormone binding globulin (SHBG) concentrations than controls (61 ± 17 nmol/L vs. 83 ± 18.1 nmol/L; P = .001), which were even lower in the PCOS group (39.5 ± 12.9 nmol/L; P = .001 compared with T1DM). The free androÂgen index (FAI) was higher in the PCOS group compared with both other groups (T1DM vs. PCOS vs. controls: 2.53 ± 0.54 vs. 7.88 ± 1.21 vs. 1.6 ± 0.68; P<.001). FAI was higher in patients with T1DM compared to controls as well (P = .038). There was no difference in DHEA-S concentraÂtions between T1DM and PCOS patients (269 ± 112 μg/dL vs. 297 ± 100 μg/dL; P>.05). Conclusion: Menstrual disorders and androgen-relatAêd traits in young women with T1DM may be attributed to an increase in androgen bioavailability due to decreased SHBG concentrations. © Copyright © 2020 AACE.
Συγγραφείς:
Paschou, S.A.
Vryonidou, A.
Melissourgou, M.
Kosteria, I.
Goulis, D.G.
Chrousos, G.P.
Kanaka-Gantenbein, C.
Περιοδικό:
Endocrine Practice
Εκδότης:
American Association of Clinical Endocrinologists
Λέξεις-κλειδιά:
adiponectin; androgen; androstenedione; follitropin; globulin; glutamate decarboxylase; glycosylated hemoglobin; hemoglobin A1c; hormone binding protein; insulin; leptin; levothyroxine; luteinizing hormone; prasterone sulfate; prolactin; sex hormone; sex hormone binding globulin; sulfuric acid; testosterone; thyroid peroxidase antibody; thyrotropin; zinc transporter; androgen; sex hormone binding globulin; testosterone, acne; acne vulgaris; adolescent; adult; albuminuria; Article; autoimmune disease; autoimmune thyroiditis; bioavailability; celiac disease; clinical article; controlled study; cross-sectional study; diabetic retinopathy; disease duration; eating disorder; female; food frequency questionnaire; gestational age; glucose blood level; glycemic control; high performance liquid chromatography; hirsutism; homeostasis model assessment; human; hyperandrogenism; hyperglycemia; hypoglycemia; hypogonadism; hypophysis adenoma; hypothyroidism; immunoradiometric assay; insulin dependent diabetes mellitus; insulin release; ketoacidosis; major clinical study; menarche; menstrual cycle; menstruation disorder; non insulin dependent diabetes mellitus; obesity; oligomenorrhea; oral glucose tolerance test; ovary function; ovary polycystic disease; prevalence; primary amenorrhea; prospective study; waist circumference; insulin dependent diabetes mellitus; ovary polycystic disease; young adult, Adolescent; Adult; Androgens; Diabetes Mellitus, Type 1; Female; Humans; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Testosterone; Young Adult
DOI:
10.4158/EP-2020-0153
