Τίτλος:
Demographic, clinical and hormonal characteristics of patients with premature ovarian insufficiency and those of early menopause: data from two tertiary premature ovarian insufficiency centers in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the study was to compare demographic, hormonal and clinical parameters in patients with premature ovarian insufficiency (POI) and women with early menopause in Greece. One hundred thirty-nine women of Greek origin, aged 14–45 years, referring for oligomenorrhea and having elevated FSH concentrations were divided into three groups regarding the age of menstrual disturbances onset [POI1: </=30 years (n = 42); POI2: 31–39 years (n = 36); early menopause: 40–45 years (n = 61)]. The mean age of menstrual disturbances onset and that of diagnosis in all POI and early menopause patients were 28.7 years (28.7 ± 7.7) versus 42.1 years (42.1 ± 1.5) and 33.8 years (33.8 ± 7.2) versus 43.3 years (43.3 ± 1.4), respectively. POI patients and women with early menopause were diagnosed, respectively, five years and approximately four to six months later than the age of menstrual disturbances onset. Moreover, FSH2 (second confirmatory FSH measurement at 4-to-6-weeks interval) was greater in all POI patients than in early menopause women (55.4 ± 33.9 vs. 32.4 ± 19.4; p <.05) whereas mean age of menarche was greater in early menopause women than in POI patients (13 ± 1.3 vs. 12 ± 2.2; p <.05). Furthermore, FSH2 was increased in all POI and decreased in early menopause patients. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Bompoula, M.S.
Valsamakis, G.
Neofytou, S.
Messaropoulos, P.
Salakos, N.
Mastorakos, G.
Kalantaridou, S.N.
Περιοδικό:
Gynecological Endocrinology
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
estradiol; follitropin; luteinizing hormone; Muellerian inhibiting factor; prolactin; thyrotropin; estradiol; follitropin; hormone, adolescent; adult; amenorrhea; antral follicle count; Article; autoimmune disease; bone density; clinical feature; controlled study; demography; dual energy X ray absorptiometry; early menopause; family history; female; female subfertility; follitropin blood level; Greece; gynecologic surgery; hormone substitution; hot flush; human; hypothyroidism; libido disorder; major clinical study; maternal age; menarche; menstruation disorder; mood change; night sweat; oligomenorrhea; osteopenia; osteoporosis; patient history of surgery; pregnancy; premature ovarian failure; primary amenorrhea; priority journal; secondary amenorrhea; smoking; Turner syndrome; vaginal dryness; blood; female infertility; middle aged; physiology; premature ovarian failure; risk factor; young adult, Adolescent; Adult; Demography; Estradiol; Female; Follicle Stimulating Hormone; Greece; Hormones; Humans; Infertility, Female; Menopause, Premature; Middle Aged; Primary Ovarian Insufficiency; Risk Factors; Young Adult
DOI:
10.1080/09513590.2020.1739266
