Τίτλος:
Autophagy and salivary gland cancer: A putative target for salivary gland tumors
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Salivary gland carcinomas are a group of heterogeneous tumors of different histological subtypes, presenting relatively low incidence but the entire variable of types. Although novel treatment options for salivary gland carcinomas patients’ outcomes have improved, the treatment of this type of cancer is still not standardized. In addition, a significant number of patients, with a lack of optimal treatment strategies, have reduced survival. In the last two decades, a plethora of evidence pointed to the importance of autophagy, an essential catabolic process of cytoplasmatic component digestion, in cancer. In vitro and in vivo studies highlight the importance of autophagy in salivary gland carcinomas development as a tumor suppressor or promoter mechanism. Despite the potential of autophagy in salivary gland carcinomas development, no therapies are currently available that specifically focus on autophagy modulation in salivary gland carcinomas. In this review, we summarize current knowledge and clinical trials in regard to the interplay between autophagy and the development of salivary gland carcinomas. Autophagy manipulation may be a putative therapeutic strategy for salivary gland carcinomas patients. © The Author(s) 2020.
Συγγραφείς:
Koustas, E.
Sarantis, P.
Theodorakidou, M.
Karamouzis, M.V.
Theocharis, S.
Εκδότης:
SAGE Publications Ltd
Λέξεις-κλειδιά:
8 [4 (1 aminocyclobutyl)phenyl] 9 phenyl 1,2,4 triazolo[3,4 f][1,6]naphthyridin 3(2h) one; buparlisib; cetuximab; everolimus; ipilimumab; nivolumab; paclitaxel; panitumumab; pembrolizumab; sepantronium bromide; temsirolimus; tumor marker, antineoplastic activity; autophagosome; autophagy (cellular); cancer chemotherapy; cancer growth; cancer immunotherapy; cancer inhibition; cancer radiotherapy; cancer surgery; cancer therapy; carcinogenesis; cell function; clinical trial (topic); disease association; human; macroautophagy; molecularly targeted therapy; nonhuman; patient care; priority journal; Review; salivary gland carcinoma; salivary gland function; animal; autophagy; metabolism; pathology; salivary gland tumor, Animals; Autophagy; Biomarkers, Tumor; Humans; Salivary Gland Neoplasms
DOI:
10.1177/1010428320980568
