Τίτλος:
Primary sarcoma of the lung - Prognostic value of clinicopathological characteristics of 26 cases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: Primary sarcomas of the lung (PSL) represent a rare, largely unknown entity. We herein present a retrospective study of 26 patients diagnosed with PSL. Patients and Methods: For a period of 10 years, the records of patients from 5 centers were gathered and analyzed. Results: Median age at diagnosis was 61.96 years (range=31-75 years). Eight patients (33.33%) had mediastinal node invasion (MNI). From 17 patients (70.83%) with localized disease, 11 patients (64.70%) underwent surgery. Recurrence rate was 72.72%. Median disease-free interval was 15 months. The median overall survival (OS) of patients with metastatic disease was 4 months and 10 months for the whole population. Only surgery had an impact on survival. Conclusion: Prognosis of PSL is somber. The high proportion of patients with MNI at diagnosis may serve as an indication for surgical evaluation of mediastinum and raises the question whether patients with locoregional PSL should be treated with a more aggressive approach. © 2020 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Duran-Moreno, J.
Kokkali, S.
Ramfidis, V.
Salomidou, M.
Digklia, A.
Koumarianou, A.
Tomos, P.
Koufopoulos, N.
Vamvakaris, I.
Psychogiou, E.
Syrigos, K.
Περιοδικό:
ANTICANCER RESEARCH
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
antineoplastic agent; doxorubicin; ifosfamide, adjuvant chemotherapy; adult; aged; angiosarcoma; Article; cancer prognosis; cancer recurrence; cancer staging; cancer surgery; cancer survival; clinical article; disease free interval; epithelioid sarcoma; female; human; lung sarcoma; male; mediastinum lymph node; middle aged; neoadjuvant chemotherapy; overall survival; plasma cell granuloma; postoperative complication; primary tumor; priority journal; recurrence risk; recurrent disease; retrospective study; synovial sarcoma; tumor invasion; tumor volume; lung tumor; mortality; pathology; prognosis; sarcoma; survival rate, Adult; Aged; Female; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Sarcoma; Survival Rate
DOI:
10.21873/anticanres.14122
