Περίληψη:
The purpose of the present study was to evaluate the relation of the
systemic arterial pulse pressure and other parameters derived from the
24-h arterial blood pressure (BP) monitoring to the severity of coronary
artery disease, carotid lesions, and left ventricular (LV) mass index in
patients without arterial hypertension. One hundred ten patients with
known coronary artery disease underwent coronary arteriography, 24-h
arterial BP monitoring, and ultrasound imaging of the carotid arteries
and the myocardium. Measurements of 24-h arterial BP monitoring
(systolic, diastolic, and average BP, pulse pressure, abnormal values of
systolic and diastolic BP, and heart rate), the severity of coronary
heart disease (Gensini score), intima-media thickness (IMT) of the
common carotid artery and LV mass index were determined in all patients.
By univariate analysis, only 24-h pulse pressure was significantly
related to the severity of coronary artery disease (P < .01), carotid
IMT(P (.01), and LV mass index (P < .01). In a multivariate analysis,
24-h pulse pressure was also the best predictor of the severity of
coronary lesions (P = .009), carotid IMT (P = .003), and LV mass index
(P = .009). Gensini score was related (P < .01) to LV mass index and not
to carotid IMT. In conclusion, systemic arterial pulse pressure derived
from 24-h arterial BP monitoring is related to coronary artery disease,
carotid IMT, and LV mass index independently of age or any other
derivative of 24-h arterial BP monitoring, indicating that this
parameter could be a marker of global cardiovascular risk. (C) 2001
American Journal of Hypertension, Ltd.
Συγγραφείς:
Zakopoulos, NA
Lekakis, JP
Papamichael, CM
Toumanidis, ST
and Kanakakis, JE
Kostandonis, D
Vogiazoglou, TJ and
Rombopoulos, CG
Stamatelopouos, SF
Moulopoulos, SD
