Τίτλος:
G-CSF induces elevation of circulating CA 15-3 in breast carcinoma
patients treated in an adjuvant setting
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
BACKGROUND. Cancer antigen 15-3 (CA 15-3), a circulating marker that
determines secreted products of the polymorphic MUC1 gene, has been
established as a conveniens tool for monitoring breast carcinoma
patients.
METHODS. The authors investigated alterations of soluble CA 15-3 in 57
postoperative breast carcinoma patients while they were receiving
intensified adjuvant chemotherapy with granulocyte colony stimulating
factor (G-CSF) support; 26 patients had American Joint Committee on
Cancer (AJCC) Stage II, and 31 patients had AJCC Stage III breast
carcinoma. Serial CA 15-3 values recorded thoughout the treatment were
compared with baseline values, analyzed for correlation with hematologic
and biochemical parameters, and compared with clinicopathologic
characteristics and patient outcome. At a median follow-up time of 32
months, 47 of these patients remained relapse-free.
RESULTS. A twofold increase of CA 15-3 was detected at the end of the
second week of treatment, remained significantly elevated in most
patients at above the cutoff level of 30 U/mL throughout the treatment
period (P < 0.0001), and subsided to pretreatment values 1-2 months
after treatment cessation. CA 15-3 values were found to be associated
strongly with absolute neutrophil count, serum lactate dehydrogenase,
and alkaline phosphatase. The median values and the kinetics of tumor
markers did not differ over time in regard to hormonal receptor status
and disease recurrence.
CONCLUSIONS. These data provide strong evidence that G-CSF
administration can induce elevation of CA 15-3 and indicate that
false-positive results should be considered when evaluating CA 15-3 in
patients who are receiving G-CSF. It is speculated that this phenomenon
occurs through the induction of MUC1 antigen of unknown origin by G-CSF.
Experimental investigation of this clinical observation is warranted.
(C) 2001 American Cancer Society.
Συγγραφείς:
Briasoulis, E
Andreopoulou, E
Tolis, CF
Bairaktari, E and
Katsaraki, A
Dimopoulos, MA
Fountzilas, G
Seferiadis, G and
Pavlidis, N
Εκδότης:
Wiley-Liss, Inc.
Λέξεις-κλειδιά:
granulocyte colony stimulating factor; cancer antigen 15-3; MUC1; breast
carcinoma; adjuvant chemotherapy; intensified chemotherapy
DOI:
10.1002/1097-0142(20010301)91:5<909::AID-CNCR1080>3.3.CO;2-O
