Τίτλος:
Endoscopic implantation of Plexiglas (PMMA) microspheres for the
treatment of GERD
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: A gelatinous implant containing polymethylmethacrylate
(PMMA) beads is successfully used to augment the diminished thickness of
the chorium in patients with skin defects and wrinkles, The aim of the
present study was to determine whether submucosal injection of PMMA
microspheres into the lower esophageal folds decreases the severity of
symptoms and acid reflux in patients with GERD.
Methods: Endoscopic submucosal implantation of PMMA was carried out in
10 patients with GERD who were either refractory to or dependent on
proton pump inhibitors. Symptom severity score, 24-hour pH monitoring,
upper GI endoscopy, and EUS were performed to evaluate the efficacy of
implantation.
Results: A significant decrease in the symptom severity score and mean
total time with esophageal pH less than 4 was noted after the
implantation of PMMA (p < 0.05). Seven of 10 patients were taking no
medication after PMMA implantation, There were no serious
procedure-related complications.
Conclusions: Endoscopic implantation of PMMA into the submucosa of the
lower esophageal folds may be a new method for treating GERD, Further
studies are required to determine the longterm efficacy of the
procedure.
Συγγραφείς:
Feretis, C
Benakis, P
Dimopoulos, C
Dailianas, A and
Filalithis, P
Stamou, KM
Manouras, A
Apostolidis, N
Περιοδικό:
Gastrointestinal Endoscopy
Εκδότης:
Mosby Year Book Inc
DOI:
10.1067/mge.2001.113912
