Τίτλος:
Risk factors predisposing to fetal loss following a second trimester
amniocentesis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective To examine the influence of possible risk factors on fetal
loss rate following amniocentesis.
Design Retrospective analysis of case records between 1993 and 1998.
Setting Fetal medicine unit of a large teaching hospital.
Population One thousand and six women with singleton pregnancies formed
the study group. Seven hundred and eight of them had bleeding during the
current pregnancy before the procedure, while 298 had a history of three
or more first trimester abortions and/or a second trimester miscarriage
or termination of pregnancy. Four thousand and twenty-four women who had
amniocentesis and had no risk factors served as controls. Both groups
were also classified according to maternal age. Group 1: 1610 women aged
20-34 years: Group 2: 2850 women aged 35-39 years; Group 3; 570 women >
40 years.
Methods Women of both groups underwent a second trimester amniocentesis
between 16 and 21 weeks of gestation. Fetal losses following
amniocentesis were examined in three time intervals: 1. in the first two
weeks after the procedure; 2. up to the 28(th) week; 3. from the 28(th)
week to term.
Results There was a statistically significant difference in the fetal
loss rate between women aged 20-34 years (2.54%) and those > 40 years
(5. 1 %). Women with a history of vaginal bleeding during the current
pregnancy had a higher fetal loss rate compared with controls (6.5% vs
2.8%), which corresponds to an odds ratio of 2.4 (95% Cl 1.69-3.42). A
similar difference was found between the group of women with a history
of previous abortions/terminations and the controls (8% vs 2.8%): OR
3.03 (95% Cl 1.92-4.79).
Conclusions There is a higher risk of fetal loss following amniocentesis
in women > 40 years of age compared with those aged 20-34 years.
Bleeding in the current pregnancy, a history of three or more first
trimester abortions, a second trimester miscarriage or termination of
pregnancy seem to be significant predisposing factors for fetal loss
after an amniocentesis.
Συγγραφείς:
Papantoniou, NE
Daskalakis, GJ
Tziotis, JG
Kitmirides, SJ
and Mesogitis, SA
Antsaklis, AJ
Περιοδικό:
British Journal of Obstetrics and Gynaecology
DOI:
10.1016/S0306-5456(01)00246-7
