Τίτλος:
C-myc and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and
malignant mesenchymal tumors
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Mouse coding region determinant-binding (mCRD-BP) and human IGF-II
mRNA-binding 1 (hIMP-1) proteins are orthologous mRNA-binding proteins
that recognize c-myc and IGF-II mRNA, respectively, and regulate their
expression posttranscriptionally. Here, we confirm that human
CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed
in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in
cell lines of neoplastic origin and in selected primary tumors. In a
series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%,
respectively, were found to express hCRD-BP/IMP-1. In particular,
expression was significant in 14 Ewing’s sarcomas, all of which were
positive. The data suggest that hCRD-BP/IMP-1 plays a role in abnormal
cell proliferation in mesenchymal tumors. (C) 2001 Wiley-Liss, Inc.
Συγγραφείς:
Ioannidis, P
Trangas, T
Dimitriadis, E
Samiotaki, M and
Kyriazoglou, I
Tsiapalis, CM
Kittas, C
Agnantis, N and
Nielsen, FC
Nielsen, J
Christiansen, J
Pandis, N
Περιοδικό:
International Journal of Cancer
Λέξεις-κλειδιά:
mRNA-binding protein; c-myc; IGF-II; mesenchymal tumor; c-myc coding
region determinant-binding protein; IGF-II; mRNA-binding protein-1
