Περίληψη:
In this prospective study, the 24-hour gastric aspirate volume was
carefully recorded before, 24 and 48 h after administering 1.7
mg/kg/8-hourly of oral erythromycin to 16 ventilated neonates less than
32 weeks of gestation. Their median gestational age was 28.5 weeks
(range 2331 weeks), their median birthweight was 1,045 g (range
690-1,560 g) and the median day of life at which erythromycin was
commenced was 9.5 days (range 4-16 days). Prior to administering
erythromycin median 24-hour gastric aspirate volume, expressed as a
percentage of the milk volume given over the same period, was 38.5%
(range 20.0-100%). It was significantly lower 24 h (median 12%, range
0-41%, p = 0.0004) and 48 h (median 5%, range 0-21%, p = 0.0004)
after commencing erythromycin. There was also significant reduction of
gastric aspirate volume between 24 and 48 h after commencing
erythromycin (p = 0.0024). Milk volume increment over the same period
was not significant (p = 0.1022). These preliminary results warrant
further evaluation through a randomised controlled trial.
Συγγραφείς:
Dellagrammaticas, HD
Iacovidou, N
Megaloyanni, E and
Papadimitriou, M
Kapetanakis, J
