Τίτλος:
Detection of CD55-and/or CD59-deficient red cell populations in patients
with plasma cell dyscrasias
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder
characterized by a decrease or absence of glycosylphosphatidylinositol
(GPI)-anchored molecules such as CD55 and CD59 from the surface of
affected cells. resulting in intravascular hemolysis. cytopenia, and
venous thrombosis. A PNH-like phenotype has been detected in various
hematological disorders, mainly in aplastic anemia and myelodysplastic
syndromes, but also in lymphoproliferative syndromes (LPSs). To the best
of our knowledge. CD55- or CD59-deficient red cells have not been
detected in Plasma cell dyscrasias (PCDs). The aim of this study was the
detection of CD55- and/or CD59-deficient red cell populations in
patients with PCD. Seventy-seven patients were evaluated; 62 with
multiple myeloma (MM), 7 with Waldenstrom macroglobulinemia (WM), 6 with
monoclonal gammopathy of undetermined significance (MGUS), and 2 with
heavy chain disease (HCD). The sephacryl gel microtyping system was
applied: Ham and sucrose lysis tests were also performed on all samples
with CD55- or CD59-negative populations. Red cells deficient in both
molecules were detected in 10 (12.9%) of 77 patients with PCD: 2
(28.6%) of 7 with WM, 1 (16.6%) of 6 with MGUS, 6 (9.6%) of 62 with
MM, and 1 of 2 patients with HCD. Isolated CD55 deficiency was found in
28.5% of all PCD patients. whereas isolated CD59 deficiency was not
observed in any patients. These findings illustrate the existence of the
PNH phenotype in the red cells of patients with PCD: further
investigation is needed into the mechanisms and significance of this
phenotype. Int J Hematol. 2002;75:40-44. (C) 2002 The Japanese Society
of Hematology.
Συγγραφείς:
Meletis, J
Terpos, E
Samarkos, M
Meletis, C
Apostolidou,
E
Komninaka, V
Korovesis, K
Anargyrou, K
Benopoulou, O
and Mavrogianni, D
Variami, E
Viniou, N
Konstantopoulos, K
Περιοδικό:
International Journal of Hematologic Oncology
Εκδότης:
SPRINGER JAPAN KK
Λέξεις-κλειδιά:
paroxysmal nocturnal hemoglobinuria; CD55; CD59; multiple myeloma;
Waldenstrom macroglobulinemia
