Περίληψη:
Objective To compare the expression of intercellular adhesion molecule-1
(ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), platelet
endothelial cell adhesion molecule-1 (PECAM-1) and E-selectin in
placental bed biopsies (endothelium of spiral arteries as well as
trophoblastic cells) from normal and pre-eclamptic pregnancies.
Design A prospective study.
Setting 1. First Department of Obstetrics and Gynaecology, Alexandra
Hospital, University of Athens, Greece. 2. Laboratory of
Pathophysiology, Laikon Hospital, University of Athens.
Population Sixteen placental bed biopsies from women with pre-eclampsia
were compared with 20 placental bed biopsies from uncomplicated
normotensive women.
Main outcome measures Immunocytochemical staining of the placental bed
biopsies for ICAM-1, VCAM-1, PECAM-1 and E-selectin.
Results No statistically significant differences were found in the
expression of the adhesion molecules ICAM-1, VCAM-1, PECAM-1 and
E-selectin in the endothelium of the spiral arteries and the
trophoblastic cells of the placental bed of the two studied groups.
Conclusions Adhesion molecules ICAM-1, VCAM-I, PECAM-1, but not
E-selectin, are expressed in the placental bed of normal and
pre-eclamptic pregnancies, but there are no differences between the two
groups of women. It seems that the above molecules are not likely to be
implicated in the aetiology of pre-eclampsia.
Συγγραφείς:
Tziotis, J
Malamitsi-Puchner, A
Vlachos, G
Creatsas, G and
Michalas, S
