Τίτλος:
Total and HDL cholesterol and risk of stroke. EUROSTROKE: a
collaborative study among research centres in Europe
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Controversy remains on the relation between serum lipids
levels and stroke risk. This paper investigated the association of total
and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and
ischaemic stroke in four European cohorts participating in EUROSTROKE.
Methods: EUROSTROKE is a collaborative project among ongoing European
cohort studies on incidence and risk factors of stroke. EUROSTROKE is
designed as a nested case-control study. For each stroke case, two
controls were sampled. Strokes were classified according to MONICA
criteria or reviewed by a panel of four neurologists. At present, data
on stroke and risk factors were available from cohorts in Cardiff (84
cases), Kuopio (74 cases), Rotterdam (157 cases), and Novosibirsk (79
cases).
Results: Pooled analyses showed no significant association between total
cholesterol and risk of stroke (odds ratio for increase of 1 mmol/l in
cholesterol of 0.98 (95% CI 0.88 to 1.09)). Analyses for haemorrhagic
stroke and cerebral infarction revealed odds ratios of 0.80 (95% CI
0.61 to 1.05) and 1 06 (95% CI 0.94 to 1.19), respectively. The
association of HDL cholesterol to stroke was different in men compared
with women. In men, there was a general trend towards a lower risk of
stroke with an increase in HDL (odds ratio per 1 mmol/l increase in HDL
cholesterol 0.68 (95% CI 0.40 to 1.16)). In women however, an increase
in HDL was associated with a significant increased risk of non-fatal
stroke and of cerebral infarction (odds ratios of 2.46 (95% 0.1.20 to
5.04) and 2.52 (95% CI 1.15 to 5.50), respectively. The difference
between men and women in the association of HDL with stroke seemed to
differ mainly in smokers and never smokers, but not among ex smokers.
Conclusion: This analysis of the EUROSTROKE project could not disclose
an association of total cholesterol with fatal, non-fatal, haemorrhogic
or ischaemic stroke. HDL cholesterol however, seemed to be related to
stroke differently in men than in women.
Συγγραφείς:
Bots, ML
Elwood, PC
Nikitin, Y
Salonen, JT
de Concalves,
AF
Inzitari, D
Sivenius, J
Benetou, V
Tuomilehto, J and
Koudstaal, PJ
Grobbee, DE
Περιοδικό:
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
Εκδότης:
BMJ Publishing Group
DOI:
10.1136/jech.56.suppl_1.i19
