Τίτλος:
P53 possibly upregulates the expression of CD58 (LFA-3) and CD59 (MIRL)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
P53 is an oncosuppressor protein which acts via transcriptional and
non-transcriptional mechanisms. The transcriptional function of p53 is
mediated by specific responsive elements (RE). In the present study we
found one perfect p53 RE located in the first intron of the gene
encoding for CD58 (lymphocyte function Antigen -3/LFA-3) membrane
protein. Additionally, we detected one perfect p53 RE within the
promoter region and one imperfect p53 RE placed in the first intron of
the gene encoding for CD59 (membrane inhibitor of reactive lysis/MIRL).
The results of our investigation suggest that p53 may enhance the
transcription of both CD59 and CD58 and imply a novel role for p53 as a
direct regulator of the immune response. (C) 2002 Harcourt Publishers
Ltd.
Συγγραφείς:
Sampaziotis, F
Kokotas, S
Gorgoulis, VG
Περιοδικό:
Medical Hypotheses
Εκδότης:
Churchill Livingstone
DOI:
10.1054/mehy.2001.1476
