Περίληψη:
Reports of substantial evidence for genetic linkage of schizophrenia to
chromosome 1q were evaluated by genotyping 16 DNA markers across 107
centimorgans of this chromosome in a multicenter sample of 779
informative schizophrenia pedigrees. No significant evidence was
observed for such linkage, nor for heterogeneity in allele sharing among
the eight individual samples. Separate analyses of European-origin
families, recessive models of inheritance, and families with larger
numbers of affected cases also failed to produce significant evidence
for linkage. If schizophrenia susceptibility genes are present on
chromosome 1q, their population-wide genetic effects are likely to be
small.
Συγγραφείς:
Levinson, DF
Holmans, PA
Laurent, C
Riley, B
Pulver, AE
and Gejman, PV
Schwab, SG
Williams, NM
Owen, MJ and
Wildenauer, DB
Sanders, AR
Nestadt, G
Mowry, BJ
Wormley,
B
Bauche, S
Soubigou, S
Ribble, R
Nertney, DA
Liang,
KY
Martinolich, L
Maier, W
Norton, N
Williams, H and
Albus, M
Carpenter, EB
deMarchi, N
Ewen-White, KR
Walsh,
D
Jay, M
Deleuze, JF
O'Neill, FA
Papadimitriou, G and
Weilbaecher, A
Lerer, B
O'Donovan, MC
Dikeos, D and
Silverman, JM
Kendler, KS
Mallet, J
Crowe, RR
Walters, M
