Τίτλος:
Risk factors for medullary thyroid carcinoma: a pooled analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate risk factors for medullary thyroid cancer
(MTC).
Methods: We conducted a pooled analysis of 14 case-control studies from
Europe, North America, and Asia, including 67 medullary cancers (43
women and 24 men) diagnosed in ten studies. Of the original 4776, we
selected five controls per case matched on study, gender, and age. The
pooled odds ratios (OR) were estimated using conditional logistic
regression.
Results: Education, weight, and body mass were not associated with MTC,
but a significant positive relationship was seen with height (OR = 2.6
for highest vs lowest tertile). Significant excess risks were associated
with a history of thyroid nodules (OR = 12), hypertension (OR = 2.3),
gallbladder disease (OR = 4.3), and allergies (OR = 2.2). Among current
smokers, a decreased risk of MTC was observed with increasing number of
cigarettes. The risk was significantly elevated among women having a
first birth after age 25 years, but no clear pattern emerged for other
reproductive factors.
Conclusions: Although the number of MTC was small, we detected several
significant associations, including prior thyroid and other diseases.
Συγγραφείς:
Negri, E
Ron, E
Franceschi, S
La Vecchia, C and
Preston-Martin, S
Kolonel, L
Kleinerman, RA
Mabuchi, K and
Jin, F
Wingren, G
Hallquist, A
Levi, F
Linos, A and
Fraumeni, JF
Περιοδικό:
Cancer Causes and Control
Εκδότης:
KLUWER ACADEMIC PUBL
Λέξεις-κλειδιά:
case-control studies; epidemiology; medullary thyroid carcinoma; risk
DOI:
10.1023/A:1015263718760
