Τίτλος:
Expression of mos in astrocytic tumors and its potential role in
neoplastic progression
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The c-mos gene and its protein product mos, components of the
mitogen-activated protein kinase transduction pathway, are known to be
involved in the control of meiosis and mitosis. Apart from a study on
lung carcinomas, there is little information about its role in human
neoplasia. The aim of this study was to investigate expression of mos in
astrocytic tumors and to correlate it with accumulation of p53. We
studied expression of mos in 62 cases of supratentorial astrocytic
tumor. Intracytoplasmic immunostaining for mos was found in 28 (45%)
cases: 3 of 20 (15%) grade 2 astrocytomas, 9 of 20 (45%) grade 3
anaplastic astrocytomas, and 16 of 22 (73%) glioblastomas.
Immunopositivity for mos correlated significantly (P < 0.01) with tumor
grade but not with p53 expression. In contrast to the findings in
relation to lung tumors, immunopositivity for mos in astrocytic tumors
did not predict recurrence-free or overall survival time. Cyto-plasmic
immunostaining was observed in scattered large cortical neurons adjacent
to tumors, possibly due to stress-induced abortive entry into the cell
cycle. The correlation of mos immunopositivity with tumor grade may
reflect the expansion of more malignant mos-positive clones. This study
provides evidence that mos may be involved in the neoplastic progression
of a proportion of astrocytic tumors. Hum PATROL 33:703-707. Copyright
2002, Elsevier Science (USA). All rights reserved.
Συγγραφείς:
Perunovic, B
Athanasiou, A
Quilty, RD
Gorgoulis, VG and
Kittas, C
Love, S
Περιοδικό:
HUMAN PATHOLOGY
Εκδότης:
W B SAUNDERS CO LTD
Λέξεις-κλειδιά:
astrocytoma; astrocytic neoplasms; c-mos gene; immunohistochemistry;
brain neoplasms; lymphokines; p53; proto-onko gene proteins mos
DOI:
10.1053/hupa.2002.125377
