Περίληψη:
Tissue inhibitor of metalloproteinase-1 (TIMP-1) has emerged as a
multifunctional protein with the contrasting activities of inhibiting
tissue,degrading enzymes and promoting cellular growth. In an attempt to
elucidate the clinical significance of TIMP-1 in breast cancer, the
expression of TIMP-1 mRNA was evaluated in 117 invasive breast
carcinomas by mRNA in situ hybridization, in correlation with
clinicopathological parameters, immunohistochemical prognostic factors
(Ki-67, c-erb-B-2, bcl-2) and clinical outcome. TIMP-1 was detected in
stromal cells in areas within the tumours and at the, tumour margin.
High TIMP-I mRNA expression in the marginal portion of the tumours was
significantly correlated with lymph node metastasis (p<0.05) and
c-erbB-2 expression (p<0.05). On the other hand. increased TIMP-1 mRNA
expression within the tumours showed a statistically significant
correlation with ER detection (p<0.01). Multivariate analysis revealed
worse survival for patients with high TIMP-1 mRNA expression in the
marginal portion of the tumours; the subgroup of these patients
co-expressing high levels of TIMP-1 mRNA within the tumours as well had
even worse survival (p=0.042). In conclusion, our data support the
multifunctional role of TIMP-1, particularly its growth-promoting
activity, on the basis of its significant correlation with lymph node
metastasis and adverse prognosis. In addition to the latter property, a
probable association of TIMP-1 with tumour cell differentiation is
suggested by its topographical correlation with ER detection. Copyright
(C) 2002 John Wiley & Sons, Ltd.
Συγγραφείς:
Nakopoulou, L
Giannopoulou, I
Stefanaki, K
Panayotopoulou, E
and Tsirmpa, I
Alexandrou, P
Mavrommatis, J
Katsarou, S and
Davaris, P
