Τίτλος:
Serum Apolipoprotein AI levels in atherosclerotic and diabetic patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: to evaluate the association between Apolipoprotein AI
(ApoAI), Apolipoprotein B100 (ApoB) and the presence of lower limb
atherosclerotic occlusive disease.
Materials and methods: serum lipids, lipoprotein fractions, ApoAI, ApoB
and Lp(a) were measured in 52 patients (28 diabetics and 24
non-diabetics) with lower limb occlusive disease. They were evaluated
according to patients’ glucose and compared with those in 75 healthy
controls.
Results: there was a significant decrease in HDL-cholesterol and ApoAI
serum levels (p = 0.000001) and an increase in Lp(a) (p = 0.000001) in
patients as compared to controls. No difference was observed in total
cholesterol, non HDL-cholesterol or triglycerides. Multiple regression
analysis revealed a significant association between low ApoAI (or HDL)
levels and the disease as well as between high Lp(a) levels and the
disease.
ApoAI (p = 0.0003), HDL-cholesterol (p = 0.00005) and total cholesterol
(p = 0.01) levels were significantly lower in diabetic patients compared
to non-diabetic patients. Lp(a) levels did not correlate with fasting
glucose concentration. Multiple regression analysis revealed a
significant association between low ApoAI (or HDL) levels and diabetes.
Conclusion: decreased ApoAI appears to be a main component of the
dyslipidaemic serum profile observed in patients with atherosclerotic
occlusive disease of the lower extremities. Increased Lp(a) levels is an
independent risk factor. Decreased HDL-cholesterol is also involved in
the dyslipidaemic profile.
Συγγραφείς:
Dionyssiou-Asteriou, A
Papastamatiou, M
Vatalas, IA and
Bastounis, E
Περιοδικό:
European Journal of Vascular and Endovascular Surgery
Εκδότης:
W B SAUNDERS CO LTD
Λέξεις-κλειδιά:
apolipoprotein AI (ApoAI); high density lipoprotein (HDL); lipoprotein
(a)(Lp(a)); atherosclerotic occlusive disease; peripheral vascular
disease (PVD); diabetes
DOI:
10.1053/ejvs.2002.1678
