Τίτλος:
Common prognostic factors for stage III melanoma patients and for stage
I and II melanoma patients with recurrence to their regional lymph nodes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This study was undertaken in order to identify the prognostic factors
for stage III malignant melanoma patients. In addition we compared the
survival data of these patients with data from patients presenting with
stage I and II disease who subsequently developed a regional nodal
recurrence, in order to identify common prognostic factors and to
compare the biological behaviour of the two groups. We retrospectively
examined two groups of patients. The first consisted of 116 patients
with stage III malignant melanoma and the second consisted of 57
patients with stage I and II malignant melanoma that were found to have
regional lymph node metastases diagnosed at least 6 months after
surgical treatment of their primary lesion. The age of the patients, the
number of disease-involved lymph nodes, the site of the primary lesion
and the presence or not of palpable lymph nodes proved to be significant
prognostic factors of the first group. We also analysed the survival
data of the second group and compared it with data from the stage III
patients. The 5 year survival starting from the time after diagnosis of
the primary lesion was 47.37% compared with 25.86% in stage III
patients; however, this difference was not statistically significant.
Patients who present with stage III malignant melanoma seem to have a
more aggressive phenotype than stage I and II malignant melanoma
patients who present with recurrent disease in their regional lymph
nodes. Disease behaviour is dictated by the number of disease-involved
lymph nodes, the site of the primary lesion and the type of surgical
procedure performed (elective or therapeutic lymph node dissection). (C)
2002 Lippincott Williams Wilkins.
Συγγραφείς:
Konstadoulakis, MM
Messaris, E
Zografos, G
Ricaniadis, N and
Androulakis, G
Karakousis, C
Περιοδικό:
Melanoma Research
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
malignant melanoma; prognosis; recurrence; stage I; II; III; anatomical
site; lymph nodes; elective node dissection; therapeutic node dissection
DOI:
10.1097/00008390-200208000-00008
