Περίληψη:
The aim of this review is to present the advances in our understanding
of the progression of tumorigenesis in neuroendocrine lung tumors.
Current information on established and putative diagnostic and
prognostic markers of neuroendocrine tumors are evaluated, with a
special reference to small-cell lung carcinoma, due to its higher
incidence and aggressive behavior. The genetic and molecular changes
that accompany these neoplasms are highlighted, and factors that
influence cell-cycle progression, apoptosis, drug resistance, and escape
from immune surveillance are critically assessed.
Συγγραφείς:
Koutsami, MK
Doussis-Anagnostopoulou, I
Papavassiliou, AG and
Gorgoulis, VG
