Τίτλος:
Evidence for left ventricular dysfunction in patients with obstructive
sleep apnoea syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
There is limited information on the development of left ventricular (LV)
dysfunction in patients with obstructive sleep apnoea (OSA) in the
absence of lung and cardiac comorbidity. This study aimed to investigate
whether OSA patients without heart morbidity develop LV dysfunction, and
to assess the effect of continuous positive airway pressure (CPAP) on LV
function.
Twenty-nine OSA patients and 12 control subjects were studied using
technetium-99m ventriculography to estimate LV ejection fraction (LVEF),
LV peak emptying rate (LVPER), time to peak emptying rate (TPER), peak
filling rate (LVPFR) and time to peak filling rate (TPFR) before and
after 6 months of treatment with CPAP.
A significantly lower LVEF was found in OSA patients, compared to
control subjects, (53+/-7 versus 61+/-6%) along with a reduced LVPER
(2.82+/-0.58 versus 3.82+/-0.77 end-diastolic volumes(.)s(-1)).
Furthermore, OSA patients had significantly lower LVPFR (2.67+/-0.71
versus 3.93+/-0.58 end-diastolic volumes(.)s(-1)) and delayed TPFR
(0.19+/-0.04 versus 0.15+/-0.03 s) in comparison with the control group.
Six-months of CPAP treatment was effective in significantly improving
LVEF, LVPER, LVPFR and TPFR.
In conclusion, obstructive sleep apnoea patients without any
cardiovascular disease seem to develop left ventricular systolic and
diastolic dysfunction, which may be reversed, either partially or
completely, after 6 months of continuous positive airway pressure
treatment.
Συγγραφείς:
Alchanatis, M
Tourkohoriti, G
Kosmas, EN
Panoutsopoulos, G
and Kakouros, S
Papadima, K
Gaga, M
Jordanoglou, JB
Περιοδικό:
European Respiratory Journal
Εκδότης:
EUROPEAN RESPIRATORY SOC JOURNALS LTD
Λέξεις-κλειδιά:
cardiovascular disease; continuous positive airway pressure; ejection
fraction; left ventricular function; obstructive sleep apnoea
DOI:
10.1183/09031936.02.00278002
