Τίτλος:
Oxotechnetium (TcO)-Tc-99m[SN(R)S][S] complexes as potential 5-HT1A
receptor imaging agents
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A series of (TcO)-Tc-99m[SN(R)S][S] complexes carrying the
1-(2-methoxyphenyl)piperazine moiety on the tridentate ligand [SN(R)S]
was synthesized. For structural characterization and for in vitro
binding assays the analogous oxorhenium complexes were prepared. As
demonstrated by appropriate competition binding tests in rat hippocampal
preparations, all oxorhenium analogues showed affinity for the 5-HT1A
receptor binding sites with IC50 values at the nanomolar range (IC50 =
5.8-103 nM). All (TcO)-Tc-99m[SN(R)S]/[S] complexes showed
significant brain uptake in rats at 2 min p.i. (0.24-1.31% ID).
However, a clear correlation between distribution of radioactivity in
the brain and distribution of 5-HT1A receptors could not be established.
(C) 2002 Elsevier Science Inc. All rights reserved.
Συγγραφείς:
Papagiannopoulou, D
Pirmettis, I
Tsoukalas, C
Nikoladou, L
and Drossopoulou, G
Dalla, C
Pelecanou, M and
Papadopoulou-Daifotis, Z
Papadopoulos, M
Chiotellis, E
Περιοδικό:
Nuclear Medicine and Biology
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
oxotechnetium; oxorhenium; mixed ligand complexes; 5-HT1A receptor;
Tc-99m receptor ligand
DOI:
10.1016/S0969-8051(02)00343-8
