Τίτλος:
Alterations of systemic endotoxemia over the course of acute edematous
pancreatitis - Correlation to the advent of an infection
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aims: To define whether bacterial translocation occurs over
the course of acute edematous pancreatitis and to correlate its presence
to the advent of an infection since data in humans are lacking. Methods:
Thirty-three patients hospitalized over the period January 2000-January
2001 were subjected to venipuncture at regular time intervals for the
collection of blood samples for blood culture and for determination of
endotoxins and of C-reactive protein. Endotoxins were measured by the
Limulus assay and C-reactive protein by nephelometry. Results: A wide
range of concentrations of endotoxins was observed over the first 3 days
of the disease. Mean (+/-SE) of endotoxins was 4.01 +/- 1.36 and 2.42
+/- 0.95 EU/ml 3 and 6 h, respectively, after admission of afebrile
patients. Respective values 3 and 6 h after admission of febrile
patients were 3.03 +/- 1.14 and 5.84 +/- 2.28 EU/ml (normal <0.1 EU/ml);
these values gradually decreased after the second day. No correlation
was found between endotoxins and C-reactive protein. Endotoxins were
increased as a result of the occurrence of an infection on the third
day. Conclusions: A significant level of endotoxemia is observed over
the course of acute edematous pancreatitis, which might be correlated to
the advent of the systemic inflammatory response. Copyright (C) 2003 S.
Karger AG, Basel and IAP.
Συγγραφείς:
Giamarellos-Bourboulis, EJ
Nikou, GC
Matsaggoura, M and
Toumpanakis, C
Grecka, P
Giannikopoulos, G
Katsilambros, N
Περιοδικό:
INTERNATIONAL JOURNAL OF PANCREATOLOGY
Λέξεις-κλειδιά:
bacterial translocation; endotoxins pancreatitis; infection
