Τίτλος:
Transcriptional impairment of beta-catenin/E-cadherin complexis not
associated with beta-catenin mutations in colorectal carcinomas
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We report the absence of beta-catenin mutations in 63 sporadic
colorectal carcinomas (SCRCs) with demonstrated decreased beta-catenin
and E-cadherin mRNA expression and E-cadherin protein expression in a
subset of carcinomas examined, suggesting that beta-catenin mutations
are an extremely rare phenomenon in SCRCs and are not responsible for
the transcriptional impairment of the beta-catenin/E-cadherin adhesion
complex observed in these tumours. (C) 2003 Cancer Research UK.
Συγγραφείς:
Garinis, GA
Spanakis, NE
Menounos, OG
Manolis, EN
Peros,
G
Περιοδικό:
British Journal of Cancer
Εκδότης:
Nature Publishing Group
Λέξεις-κλειδιά:
colorectal; beta-catenin; mRNA; mutations
DOI:
10.1038/sj.bjc.6600706
