Τίτλος:
Spread of integron-associated VIM-type metallo-beta-lactamase genes
among imipenem-nonsusceptible Pseudomonas aeruginosa strains in Greek
hospitals
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Fifty-eight imipenem-nonsusceptible (MIC greater than or equal to 8
mug/ml) Pseudomonas aeruginosa strains isolated during May 2001 in 15
Greek hospitals were studied. Thirty-six isolates derived from nine
hospitals carried VIM-type metallo-beta-lactamase genes, as found by
PCR. In 34 isolates, bla(VIM) was associated with class 1 integrons of
various sizes. DNA sequencing indicated the presence of bla(VIM-2) gene
cassettes in a variety of integron structures. Random amplified
polymorphic DNA typing suggested diversity of the bla(VIM)-positive
strains. Synergy between 2-mercaptoacetic acid and imipenem indicated
carbapenemase activity in 26 bla(VIM)-positive strains.
Συγγραφείς:
Giakkoupi, P
Petrikkos, G
Tzouvelekis, LS
Tsonas, S and
Legakis, NJ
Vatopoulos, AC
THONET GREECE Study Grp
Περιοδικό:
Journal of Clinical Microbiology
Εκδότης:
AMER SOC MICROBIOLOGY
DOI:
10.1128/JCM.41.2.822-825.2003
