Τίτλος:
Remodeling of suspended small intestinal submucosa venous valve: An
experimental study in sheep to assess the host cells' origin
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
PURPOSE: To investigate the origin of host cells during remodeling of
small intestinal submucosa (SIS) square stent-based bicuspid venous
valves (VVs).
MATERIALS AND METHODS: Suspended VVs (SVVs) were developed by suspending
VVs within bare square stents so the valve elements would not contact
the vein wall after deployment. Eight SVVs were placed within the
intrahepatic and infrahepatic inferior venae cavae (IVCs) of four adult
female sheep. Eight standard VVs were implanted in the external jugular
veins of these animals for. comparison. At 5 weeks after placement, the
devices were examined for stability and patency and the animals were
killed. Gross, histologic, and scanning electron microscopic (SEM)
examinations were performed.
RESULTS: Follow-up spot radiographs and venography showed no migration
of the devices, venous occlusion, or thrombus formation. All SVVs were
intact without contact with the IVC wall. Six VVs were competent and two
were slightly tilted with some reflux. Histologic study showed
remodeling of SVVs and VVs with newly formed collagen fibers;
fibroblasts and inflammatory cells were found penetrating the SIS
leaflets and endothelial cells on the surface. SIS neovascularization
was also present. There was no difference regarding SIS remodeling
between SVVs and the free part of VV leaflets. The VV leaflets’ bases
were thicker compared to their free parts (P < .01). SEM examination
showed endothelial cells on both sides of the SVVs and VVs.
Endothelialization of the SVV central leaflet surfaces and both surfaces
of the VV leaflets was more complete than that of the peripheral
surfaces of the SVV leaflets.
CONCLUSION: SIS-based valve remodeling occurs independently of vessel
wall contact by recruitment of cells directly from the circulation.
Συγγραφείς:
Brountzos, E
Pavcnik, D
Timmermans, HA
Corless, C and
Uchida, BT
Nihsen, ES
Nakata, M
Schoder, M
Kaufman, JA
and Keller, FS
Rosch, J
Περιοδικό:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
endothelial cells; endovascular stent-grafts
DOI:
10.1097/01.RVI.0000058410.01661.62
