Τίτλος:
Protective effect of a novel antioxidant non-steroidal anti-inflammatory
agent (compound IA) on intestinal viability after acute mesenteric
ischemia and reperfusion
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Reactive oxygen species play an important role in the basic
pathophysiology of ischemia-reperfusion injury. We investigated whether
the administration of a novel non-steroidal anti-inflammatory compound
with antioxidant properties, the compound
[5-(2-amino-ethylamino)-1-phenyl-2-pentanone] (compound IA), has a
beneficial effect on the repair process of the intestinal mucosa after
transient mesenteric ischemia in a randomized blind trial. Six groups of
rats were subjected to a model of 60 min of intestinal ischemia that was
produced by occluding the superior mesenteric artery. At the end of
ischemia, compound IA was administered intravenously and the clamp was
removed allowing reperfusion. At 60 min after reperfusion, animals were
sacrificed and a 10 cm section of terminal ileum was resected. The
outcome was evaluated by histopathologic assessment, measurement of
polymorphonuclear leukocytes and the extent of lipid peroxidation
measuring the small intestine tissue malondialdehyde. After 1 h of
reperfusion, the mucosal damage was less in IA-treated rats compared
with the control group. Moreover, the number of polymorphonuclear
leukocytes in intestinal mucosa was significantly lower in IA group.
Compound IA resulted in a statistically significant reduction of the
concentration of small intestine tissue malondialdehyde, compared to
those of controls. Administration of compound IA decreased the mucosal
damage in rats that were subjected to 60 min of ischemia followed by 60
min of reperfusion. The mechanism of compound IA action is considered to
be mediated via its potent antioxidant, free radical scavenging
activities and inhibition of polymorphonuclear leukocytes infiltration.
(C) 2003 Elsevier Science B.V All rights reserved.
Συγγραφείς:
Poussios, D
Andreadou, I
Papalois, A
Rekka, E
Gavalakis,
N
Aroni, K
Kourounakis, PN
Fotiadis, C
Sechas, MN
Περιοδικό:
European Journal of Pharmacology
Εκδότης:
ELSEVIER SCIENCE BV
Λέξεις-κλειδιά:
antioxidant; non-steroidal anti-inflammatory agent; acute mesenteric
ischemia; intestinal viability; ischemia-reperfusion
DOI:
10.1016/S0014-2999(03)01488-2
