Τίτλος:
Tidal expiratory flow limitation, dyspnoea and exercise capacity in
patients with bilateral bronchiectasis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In this study the authors investigated whether expiratory How limitation
(FL) is present during tidal breathing in patients with bilateral
bronchiectasis (BB) and whether it is related to the severity of chronic
dyspnoea (Medical Research Council (MRC) dyspnoea scale), exercise
capacity (maximal mechanical power output (WRmax)) and severity of the
disease, as assessed by high-resolution computed tomography (HRCT)
scoring.
Lung function, MRC dyspnoea, HRCT score, WRmax and FL were assessed in
23 stable caucasian patients (six males) aged 56+/-17 yrs. FL was
assessed at rest both in seated and supine positions. To detect FL, the
negative expiratory pressure (NEP) technique was used. The degree of FL
was rated using a five-point FL score. WRmax was measured using a
cyclo-ergometer.
According to the NEP technique, five patients were FL during resting
breathing when supine but not seated, four were FL both seated and
supine, and 14 were NFL both seated and supine. Furthermore, it was
shown that: 1) in stable BB patients FL during resting breathing is
common, especially in the supine position; 2) the degree of MRC dyspnoea
is closely related to the five-point FL score; 3) WRmax (% pred) is
more closely correlated with the MRC dyspnoea score than with the
five-point FL score; and 4) HRCT score is closely related to forced
expiratory volume in one second % pred but not five-point FL score.
In conclusion, flow limitation is common at rest in sitting and supine
positions in patients with bilateral bronchiectasis. Flow limitation and
reduced exercise capacity are both associated with more severe dyspnoea.
Finally, high-resolution computed tomography scoring correlates best
with forced expiratory volume in one second.
Συγγραφείς:
Koulouris, NG
Retsou, S
Kosmas, E
Dimakou, K
Malagari, K
and Mantzikopoulos, G
Koutsoukou, A
Milic-Emili, J and
Jordanoglou, J
Περιοδικό:
European Respiratory Journal
Εκδότης:
EUROPEAN RESPIRATORY SOC JOURNALS LTD
Λέξεις-κλειδιά:
bronchiectasis exercise; high-resolution computed tomography; negative
expiratory pressure; pulmonary function; respiratory mechanics
DOI:
10.1183/09031936.03.00301103
