Περίληψη:
Background Dietary fibre is thought to protect against colorectal cancer
but this view has been challenged by recent prospective and intervention
studies that showed no protective effect.
Methods We prospectively examined the association between dietary fibre
intake and incidence of colorectal cancer in 519 978 individuals aged
25-70 years taking part in the EPIC study, recruited from ten European
countries. Participants completed a dietary questionnaire in 1992-98 and
were followed up for cancer incidence. Relative risk estimates were
obtained from fibre intake, categorised by sex-specific, cohort-wide
quintiles, and from linear models relating the hazard ratio to fibre
intake expressed as a continuous variable.
Findings Follow-up consisted of 1939 011 person-years, and data for 1065
reported cases of colorectal cancer were included in the analysis.
Dietary fibre in foods was inversely related to incidence of large bowel
cancer (adjusted relative risk 0.75 [95% CI 0.59-0.95] for the
highest versus lowest quintile of intake), the protective effect being
greatest for the left side of the colon, and least for the rectum. After
calibration with more detailed dietary data, the adjusted relative risk
for the highest versus lowest quintile of fibre from food intake was
0.58 (0.41-0.85). No food source of fibre was significantly more
protective than others, and non-food supplement sources of fibre were
not investigated.
Interpretation In populations with low average intake of dietary fibre,
an approximate doubling of total fibre intake from foods could reduce
the risk of colorectal cancer by 40%.
Συγγραφείς:
Bingham, SA
Day, NE
Luben, R
Ferrari, P
Slimani, N and
Norat, T
Clavel-Chapelon, F
Kesse, E
Nieters, A
Boeing,
H
Tjonneland, A
Overvad, K
Martinez, C
Dorronsoro, M and
Gonzalez, CA
Key, TJ
Trichopoulou, A
Naska, A
Vineis, P
and Tumino, R
Krogh, V
Bueno-de-Mesquita, HB
Peeters, PHM
and Berglund, G
Hallmans, G
Lund, E
Skeie, G
Kaaks, R
and Riboli, E
