Τίτλος:
Human mast cell subtypes in conjunctiva of patients with atopic
keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson
syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Investigate mast cell (MCs) subtypes in atopic
keratoconjunctivitis (AKC), ocular cicatrical pemphigoid (OCP), and
Stevens-Johnson Syndrome (SJS). Methods: MCs subtypes were determined by
immunohistochemistry of conjunctiva (obtained from 34 patients - 9 AKC,
9 OCP, 9 SJS and 7 normal) using monoclonal antibodies directed against
chymase (MCc) and tryptase (MCT). Double staining was used to
distinguish MCS as positive for both chymase and tryptase (MCTc).
Results: The number of MCs was significantly increased in AKC, OCP and
SJS patients, compared to normal subjects. MCc were especially high in
AKC, and moderately high in OCR MC,and MCTC were similar in each disease
group. Conclusions: While the AKC findings were not surprising, the
result in OCP and SJS suggests that MCs play an underappreciated role in
the inflammatory process of these disorders. Disparate proportions of
MCS subtypes in these diseases may imply differential functions of MCs
in these disorders.
Συγγραφείς:
Yao, L
Baltatzis, S
Zafirakis, P
Livir-Rallatos, C and
Voudouri, A
Markomichelakis, NN
Zhao, TZ
Foster, CS
Περιοδικό:
Ocular Immunology and Inflammation
Εκδότης:
SWETS ZEITLINGER PUBLISHERS
DOI:
10.1076/ocii.11.3.211.17353
