Τίτλος:
An unusual case of CD4+CD7+CD56+acute leukemia with overlapping features
of type 2 dendritic cell (DC2) and myeloid/NK cell precursor acute
leukemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Type 2 dendritic cell (DC2) acute leukemia has been recently described.
We report here an unusual case of a 17-yr-old adolescent with
overlapping features of DC2 and myeloid/NK cell precursor acute leukemia
as defined by Suzuki et al. The patient presented with lymphadenopathy
and hepatosplenomegaly without extranodal manifestations in skin or
elsewhere. The morphologic, cytochemical and immunophenotypic features
were compatible with those described in DC2 acute leukemia, with
co-expression of CD4, CD56 and CD123 antigens. The novel markers BDCA-4
and BDCA-2 considered specific for DC2s were co-expressed. However,
bright CD7 positivity along with a dim expression of CD33 (57%) and
CD117 (27%) were also noted. Additionally, there was bright expression
of NG2 monoclonal antibody 7.1, a frequent finding in myeloid/NK cell
precursor acute leukemia. The interpretation of the immunophenotypic
pro. le leads to the hypothesis on the existence of borderline cases
between DC2 and myeloid/NK cell precursor acute leukemia. Still, other
hypotheses can not be overlooked, such as the possibility for a kind of
variant monoblastic leukemia or of another rare entity of acute
unclassified leukemia.
Συγγραφείς:
Anargyrou, K
Paterakis, G
Boutsis, D
Politou, M and
Papadhimitriou, SI
Siakandaris, M
Vassiliadis, J and
Androulakis, A
Meletis, J
Rombos, J
Tassiopoulou, A and
Vaiopoulos, G
Περιοδικό:
European Journal of Haematology
Λέξεις-κλειδιά:
acute unclassified leukemia; dendritic cell acute leukemia; myeloid/nk
acute leukemia
DOI:
10.1034/j.1600-0609.2003.00098.x
