Περίληψη:
We report here a case-control association study with T102C polymorphism
in the serotonin 2A receptor gene (HTR2A) in patients affected by
unipolar affective disorder (UPAD) and in controls. A total of 284
subjects were genotyped (142 UPAD and 142 controls). All subjects were
interviewed using standard diagnostic interviews and matched. A
homogenous population of unipolar patients with suicidal attempt was
identified. Conditional logistic regression was applied. No association
of the HTR2A polymorphism was found in the overall sample of 142
UPAD-control pairs regarding allele and genotype frequencies (P = 0.36
and P = 0.52 respectively) and homo heterozygote distributions (P =
0.91). This study confirms, in a multicentric European sample, the
earlier observations that the T102C HTR2A polymorphism is not associated
with UPAD. Nevertheless, a type 2 statistical error cannot be excluded.
Therefore, to exclude the implication of HTR2A in UPAD, this result must
be replicated in larger samples and in other populations using the
transmission disequilibrium test and different polymorphisms around
HTR2A. (C) 2003 Elsevier B.V./ECNP. All rights reserved.
Συγγραφείς:
Oswald, P
Souery, D
Massat, I
Del-Favero, J
Linotte, S
and Papadimitriou, G
Dikeos, D
Kaneva, R
Milanova, V and
Oruc, L
Ivezic, S
Serretti, A
Lilli, R
Van Broeckhoven,
C
Mendlewicz, J
