Τίτλος:
Blood pressure- and pulse pressure-lowering effects, Trough: Peak ratio
and smoothness index of telmisartan compared with lisinopril
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To compare lisinopril with telmisartan, in regard to: 1)
their effect on blood pressure (BP) and pulse pressure (PP), and 2) the
duration and the homogeneity of their anti hypertensive effect.
Patients and Methods: A randomized, open-label, crossover, comparative
study of telmisartan 80 mg versus lisinopril 20 mg was conducted in 32
untreated hypertensive patients using clinic and 24-hour ambulatory BP
measurements. Trough: peak ratio (TPR) and smoothness index (SI) were
calculated for each drug.
Results: Using both measurement techniques no difference was detected
between the 2 drugs in their effects either on BP (mean difference in
24-hour systolic BP 1.2 +/- 7.1 mm Hg, 95% confidence intervals -1.4,
3.8, and diastolic 0.7 +/- 5.1, -1.2, 2.5) or on PP (0.5 +/- 3.5, -0.7,
1.8). There was no difference between the TPR and the SI values of
telmisartan (TPR 0.85/0.61 for systolic/diastolic BP and SI 1.46/1.2)
and lisinopril (TPR 0.74/0.64 and SI 1.3/1.17).
Conclusions: These data suggest that telmisartan is as effective as
lisinopril in reducing BP and PP. Both drugs seem to provide smooth and
sustained effects throughout the full 24-hour period.
Συγγραφείς:
Stergiou, GS
Efstathiou, SP
Roussias, LG
Mountokalakis, TD
Περιοδικό:
Journal of Cardiovascular Pharmacology
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
ambulatory blood pressure; lisinopril; pulse pressure; smoothness index;
telmisartan; trough : peak ratio
DOI:
10.1097/00005344-200310000-00006
