Τίτλος:
Kallmann's syndrome and schizophrenia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Kallmann’s Syndrome is a heritable disorder characterized by
the association of hypogonadotropic hypogonadism and anosmia or
hyposmia. A common pathogenesis for KS and schizophrenia had been
proposed based on shared pathologies of these two disorders, although no
such clinical associations have ever been reported. Method: We report a
35 year old man with schizophrenia and Kallmann’s Syndrome. The patient
presented with signs and symptoms of hypogonadism, severe hyposmia and
normal endocrine functions of the anterior pituitary. Hyposmia has been
attributed to the absence of the olfactory bulbs and tracts and atrophy
of the olfactory gyri, but normal olfactory mucosa. The patient
presented with paranoid schizophrenia with persecutory delusions,
auditory hallucinations, thought disorder, depersonalization, and
gradual but marked global deterioration. Results: Psychiatric evaluation
revealed an entirely different psychopathological and personality
profile between the patient and the six other Kallmann patients studied.
Cycle sequencing analysis revealed a normal sequence of all 14 exons of
the KAL gene. In conclusion, based on the presented case, Kallmann’s
Syndrome and schizophrenia represent a rare clinical association rather
than a syndrome with a common pathogenesis, which if present should be
confined to the olfactory dysfunction.
Συγγραφείς:
Vagenakis, GA
Hyphantis, TN
Papageorgiou, C
Protonatariou, A
and Sgourou, A
Dimopoulos, PA
Mavreas, V
Vagenakis, AG and
Georgopoulos, NA
Περιοδικό:
The International Journal of Psychiatry in Medicine
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
schizophrenia; Kallmann’s syndrome; GnRH deficiency; KAL gene; anosmia
DOI:
10.2190/HXR5-DGRC-JCMQ-0CBH
