Τίτλος:
Effect of low doses of ionising radiation in infancy on cognitive
function in adulthood: Swedish population based cohort study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective To determine whether exposure to low doses of ionising
radiation in infancy affects cognitive function in adulthood.
Design Population based cohort study.
Setting Sweden.
Participants 3094 men who had received radiation for cutaneous
haemangioma before age 18 months during 1930-59.
Main outcome measures Radiation dose to frontal and posterior parts of
the brain, and association between dose and intellectual capacity at age
18 or 19 years based on cognitive tests (learning ability, logical
reasoning, spatial recognition) and high school attendance.
Results ne proportion of boys who attended high school decreased with
increasing doses of radiation to both the frontal and the posterior
parts of the brain from about 32% among those not exposed to around
17% in those who received >250 mGy. For the frontal dose, the
multivariate odds ratio was 0.47 (95% confidence interval 0.26 to 0.85;
P for trend 0.0003) and for the posterior dose it was 0.59 (0.23 to
1.47; 0.0005). A negative dose-response relation was also evident for
the three cognitive tests for learning ability and logical reasoning but
not for the test of spatial recognition.
Conclusions Low doses of ionising radiation to the brain in infancy
influence cognitive abilities in adulthood.
Συγγραφείς:
Hall, P
Adami, HO
Trichopoulos, D
Pedersen, NL
Lagiou, P
and Ekbom, A
Ingvar, M
Lundell, M
Granath, F
Περιοδικό:
BMJ (British Medical Journal)
Εκδότης:
BMJ Publishing Group
DOI:
10.1136/bmj.328.7430.19
