Περίληψη:
The cell proliferation markers p120, Ki-67 and proliferating cell
nuclear antigen (PCNA) recognize nuclear antigens. The expression of
these proteins by immunostaining methods was reported to be of value in
determining the prognosis of patients with malignant diseases.
In this study, we evaluated the prognostic significance of the
expression of nuclear antigens p120, PCNA and Ki-67 in prostate cancer
and compared the results with other prognostic factors.
Imprint smear samples obtained from 70 patients immediately after
radical prostatectomy for prostatic carcinoma were immunostained with
monoclonal antibodies against p120, Ki-67 and PCNA. The immunostaining
results were correlated with Gleason score, tumour differentiation,
stage and prostatic specific antigen (PSA) levels.
Our findings demonstrate that p120, Ki-67 and PCNA expression in
prostatic carcinoma smears, correlated significantly with the degree of
Gleason score (P < 0.001). When combining p120, Ki-67 and PCNA
positivity with tumour differentiation there was a significant
association among these parameters (P < 0.001). Overexpression of p120,
Ki-67 and PCNA, was also associated with increased PSA serum levels (>4
ng/ml) (P < 0.001). The distribution of p120, Ki-67 and PCNA expression
in prostate carcinomas was not statistically significant for Ki-67 (P =
0.69) and p120 (P = 0.22) but was significant for PCNA (P < 0.001) as
far as the histological stage (T2a, T2b, T2c, T3a). P120, Ki-67 and PCNA
expression had significant prognostic value for disease-free survival.
Our results conclude that nuclear antigens p120, Ki-67 and PCNA appear
to be additional markers in the field of prognosis of prostatic
carcinoma.
Συγγραφείς:
Bantis, A
Giannopoulos, A
Gonidi, M
Liossi, A and
Aggelonidou, E
Petrakakou, E
Athanassiades, P
Athanassiadou,
P
