Τίτλος:
DNA damage and repair efficiency in lymphocytes from schizophrenic
patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In the present study we examined schizophrenic patients’ lymphocytes
sensitivity to the effects of external factors, such as hydrogen
peroxide and gamma-irradiation and also their repair efficiency with the
comet assay. Our results did no show any difference in basal levels of
DNA damage between schizophrenic and normal populations. The slightly
increased sensitivity of the schizophrenic population to the externally
induced DNA damage compared to controls was not statistically
significant. Also the small reduction in the DNA repair efficiency in
schizophrenics in comparison to normal population was found to be not
statistically significant. Finally, patients with heritable
predisposition to schizophrenia did not show any difference in their
response from the other schizophrenics. (C) 2003 Elsevier Ireland Ltd.
All rights reserved.
Συγγραφείς:
Psimadas, D
Messini-Nikolaki, N
Zafiropoulou, M
Fortos, A
and Tsilimigaki, S
Piperakis, SM
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
schizophrenia; comet assay; DNA damage; humans
DOI:
10.1016/j.canlet.2003.09.022
