Τίτλος:
The effect of Ca2+ channel antagonists on plasma concentrations of
matrix metalloproteinase-2 and-9 in essential hypertension
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The ability of some antihypertensive drugs to protect from vascular
damage in hypertension might be partially due to their ability to
control matrix metalloproteinase (MMP)-mediated extracellular matrix
metabolism, which in turn may contribute to vascular remodeling. This
study was designed to investigate whether treatment with felodipine or
diltiazem has any effect on plasma levels of MMP-2 and MMP-9 in
essential hypertensive patients. We measured plasma levels of active
MMP-2 and MMP-9 in 72 hypertensive subjects and 45 controls, both before
and after 6 months of treatment with felodipine (group A) or diltiazem
(group B). Mean adjusted differences, before and after each treatment,
for MMP-2 and MMP-9 levels were: 19.8 (P = .01) for MMP-2, 0.2 (P = .5)
for MMP-9 (group A), and 1.4 (P = A) for MMP-2, 0.2 (P = .7) for MMP-9
(group 13). These findings show that MMP-2 level is raised by treatment
with felodipine but not diltiazem, whereas MMP-9 is unaffected by either
treatment. (C) 2004 American Journal of Hypertension, Ltd.
Συγγραφείς:
Zervoudaki, A
Economou, E
Pitsavos, C
Vasiliadou, K and
Aggeli, C
Tsioufis, K
Toutouza, M
Stefanadis, C and
Toutouzas, P
Περιοδικό:
American Journal of Hypertension
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
metalloproteinases; extracellular matrix; remodeling
DOI:
10.1016/j.amjhyper.2003.11.007
