Τίτλος:
European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome – Update 2017
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In order to provide a common standard for the treatment of mycosis fungoides (MF) and Sézary syndrome (SS), the European Organisation for Research and Treatment of Cancer–Cutaneous Lymphoma Task Force (EORTC-CLTF) published in 2006 its consensus recommendations for the stage-adapted selection of management options for these neoplasms. Since then, the understanding of the pathophysiology and epidemiology of MF/SS has advanced, the staging system has been revised, new outcome data have been published and novel treatment options have been introduced. The purpose of the present document is to update the original recommendations bearing in mind that there are still only a limited number of controlled studies to support treatment decisions for MF/SS and that often treatment is determined by institutional experience and availability. This consensus on treatment recommendations was established among the authors through a series of consecutive consultations in writing and a round of discussion. Recommended treatment options are presented according to disease stage, whenever possible categorised into first- and second-line options and supported with levels of evidence as devised by the Oxford Centre for Evidence-Based Medicine (OCEBM). Skin-directed therapies are still the most appropriate option for early-stage MF, and most patients can look forward to a normal life expectancy. For patients with advanced disease, prognosis is still grim, and only for a highly selected subset of patients, prolonged survival can be achieved with allogeneic stem cell transplantation (alloSCT). There is a high need for the development and investigation in controlled clinical trials of treatment options that are based on our increasing understanding of the molecular pathology of MF/SS. © 2017 The Authors
Συγγραφείς:
Trautinger, F.
Eder, J.
Assaf, C.
Bagot, M.
Cozzio, A.
Dummer, R.
Gniadecki, R.
Klemke, C.-D.
Ortiz-Romero, P.L.
Papadavid, E.
Pimpinelli, N.
Quaglino, P.
Ranki, A.
Scarisbrick, J.
Stadler, R.
Väkevä, L.
Vermeer, M.H.
Whittaker, S.
Willemze, R.
Knobler, R.
Περιοδικό:
EUROPEAN JOURNAL OF CANCER
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
alpha interferon; bexarotene; chlormethine; corticosteroid; histone deacetylase inhibitor; retinoid; antineoplastic agent; biological factor; dermatological agent, advanced cancer; allogeneic stem cell transplantation; cancer chemotherapy; cancer immunotherapy; cancer prognosis; cancer survival; consensus; consultation; human; life expectancy; medical society; mycosis fungoides; priority journal; PUVA; Review; Sezary syndrome; total skin electron therapy; cancer staging; electron; hematopoietic stem cell transplantation; immunotherapy; multimodality cancer therapy; mycosis fungoides; pathology; phototherapy; practice guideline; procedures; Sezary syndrome; Skin Neoplasms; therapeutic use; watchful waiting, Antineoplastic Combined Chemotherapy Protocols; Biological Factors; Combined Modality Therapy; Consensus; Dermatologic Agents; Electrons; Hematopoietic Stem Cell Transplantation; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Interferon-alpha; Mycosis Fungoides; Neoplasm Staging; Phototherapy; Practice Guidelines as Topic; Retinoids; Sezary Syndrome; Skin Neoplasms; Watchful Waiting
DOI:
10.1016/j.ejca.2017.02.027
